Impact of carotenoids on ulcerative colitis induced colorectal cancer - A review

AL-Noshokaty, Tohada M.; Abdelmaksoud, Nourhan M.; Abulsoud, Ahmed I.; Ahmed, Ahmed A.; Elsawy, Alaa A.; Elsayed, Amira G.; Shihata, Antonios T.; Bakhom, Anton V.; Hassan, Ashraqat M.; Badawy, Aya G.; Elsayed, Aya M.; Louis, Basanty M.; Kamel, Eman M.; Gaber, Kholoud S.; Gouda, Malak A.; Abdelwahab, Manar E.; Kamel, Marina A.; Nasry, Mina G.; Ayad, Mera N.; Talkan, Mohamed A.; Abulhamd, Omnia S.; Abdelsalam, Samaa H.; Bedeer, Seham M.; Yaseen, Tasneem G.; Abdelaziz, Yara I; Yousef, Youstena A.; Elshaer, Shereen S

doi:10.21608/ijhr.2024.274027.1001

Impact of carotenoids on ulcerative colitis induced colorectal cancer - A review

Articles in Press

Document Type : Review articles

Authors

¹ Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt

² 1- Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt 2- Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt

³ 1-Biochemistry Department, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt 2-Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt

10.21608/ijhr.2024.274027.1001

Abstract

Ulcerative colitis (UC) is one of the major forms of irritable bowel disease that is characterized by chronic inflammation of the colon and may progress into colorectal cancer (CRC), which is the second most deadly cancer all in the world. Some inflammatory mediators like tumor necrosis factor alpha (TNFα) increases resulting in a repeated cycle of inflammation leading to UC. Chronic inflammation found in CRC is believed to be due to induction of cytokines (as T cells and macrophage) and chemokines leading to alterations in proliferation, survival, and migration of epithelial cells. Particularly, inflammatory signaling pathways such as NF-κB, IL-6/ Signal transducer and activator of transcription 3 (STAT3), cyclooxygenase-2 (COX-2) / prostaglandin (PGE2), and IL-23/ Th17 have been identified in the propagation of UC related CRC and non-colitis related CRC. UC induced CRC is treated with anti-inflammatory drugs but may be associated with side effects. Therefore, carotenoids as natural drugs are used recently for the treatment of UC and CRC.

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